Product Name :
GSK1292263
Description:
GSK-1292263 is a novel GPR119 agonist that is currently under development for the treatment of type 2 diabetes. GSK1292263 improves glucose regulation in animal models of diabetes, but has no effect on plasma glucose in type 2 diabetics. Unexpectedly, GSK1292263 lowered fasting LDLc and triglycerides (TG), while increasing HDLc in the diabetic subjects. GSK1292263 has significant effects on plasma lipids and lipoprotein particles in dyslipidemic patients when dosed alone and with atorvastatin.
CAS:
1032823-75-8
Molecular Weight:
456.56
Formula:
C23H28N4O4S
Chemical Name:
2-(4-methanesulfonylphenyl)-5-(1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ylmethoxy)pyridine
Smiles :
CC(C)C1N=C(ON=1)N1CCC(COC2=CN=C(C=C2)C2=CC=C(C=C2)S(C)(=O)=O)CC1
InChiKey:
AYJRTVVIBJSSKN-UHFFFAOYSA-N
InChi :
InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Mefenamic acid Protocol
Additional information:
GSK-1292263 is a novel GPR119 agonist that is currently under development for the treatment of type 2 diabetes.Daclizumab Interleukin Related GSK1292263 improves glucose regulation in animal models of diabetes, but has no effect on plasma glucose in type 2 diabetics.PMID:32799728 Unexpectedly, GSK1292263 lowered fasting LDLc and triglycerides (TG), while increasing HDLc in the diabetic subjects. GSK1292263 has significant effects on plasma lipids and lipoprotein particles in dyslipidemic patients when dosed alone and with atorvastatin.|Product information|CAS Number: 1032823-75-8|Molecular Weight: 456.56|Formula: C23H28N4O4S|Chemical Name: 2-(4-methanesulfonylphenyl)-5-(1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-ylmethoxy)pyridine|Smiles: CC(C)C1N=C(ON=1)N1CCC(COC2=CN=C(C=C2)C2=CC=C(C=C2)S(C)(=O)=O)CC1|InChiKey: AYJRTVVIBJSSKN-UHFFFAOYSA-N|InChi: InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-19-6-9-21(24-14-19)18-4-7-20(8-5-18)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|