Product Name :
1, 3-Dicaffeoylquinic acid
Description:
1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.
CAS:
19870-46-3
Molecular Weight:
516.45
Formula:
C25H24O12
Chemical Name:
(1S,3R,4R,5R)-1,3-bis([(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy)-4,5-dihydroxycyclohexane-1-carboxylic acid
Smiles :
OC(=O)[C@@]1(C[C@@H](O)[C@@H](O)[C@@H](C1)OC(=O)/C=C/C1C=C(O)C(O)=CC=1)OC(=O)/C=C/C1C=C(O)C(O)=CC=1
InChiKey:
YDDUMTOHNYZQPO-PSEXTPKNSA-N
InChi :
InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)/b7-3+,8-4+/t19-,20-,23-,25+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.|Product information|CAS Number: 19870-46-3|Molecular Weight: 516.45|Formula: C25H24O12|Chemical Name: (1S,3R,4R,5R)-1,3-bis([(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy)-4,5-dihydroxycyclohexane-1-carboxylic acid|Smiles: OC(=O)[C@@]1(C[C@@H](O)[C@@H](O)[C@@H](C1)OC(=O)/C=C/C1C=C(O)C(O)=CC=1)OC(=O)/C=C/C1C=C(O)C(O)=CC=1|InChiKey: YDDUMTOHNYZQPO-PSEXTPKNSA-N|InChi: InChI=1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)/b7-3+,8-4+/t19-,20-,23-,25+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (193.63 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons.Conivaptan GPCR/G Protein 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A).Tris-NTA In stock 1,3-Dicaffeoylquinic acid’s anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax.PMID:32589851 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.|In Vivo:|1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.|Products are for research use only. Not for human use.|