Product Name :
(S)-Carvedilol
Description:
(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
CAS:
95094-00-1
Molecular Weight:
406.47
Formula:
C24H26N2O4
Chemical Name:
(2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]aminopropan-2-ol
Smiles :
COC1=CC=CC=C1OCCNC[C@H](O)COC1=CC=CC2NC3C=CC=CC=3C=21
InChiKey:
OGHNVEJMJSYVRP-KRWDZBQOSA-N
InChi :
InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3/t17-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Nirsevimab Biological Activity
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker.Itepekimab NF-κB (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).|Product information|CAS Number: 95094-00-1|Molecular Weight: 406.47|Formula: C24H26N2O4|Synonym:|(S)-BM 14190|Chemical Name: (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]aminopropan-2-ol|Smiles: COC1=CC=CC=C1OCCNC[C@H](O)COC1=CC=CC2NC3C=CC=CC=3C=21|InChiKey: OGHNVEJMJSYVRP-KRWDZBQOSA-N|InChi: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3/t17-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (492.04 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers.PMID:33246391 (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs.|References:|Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244.Products are for research use only. Not for human use.|