Product Name :
Ro18-5362
Description:
Ro18-5362 is the less active prodrug of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation.
CAS:
101387-97-7
Molecular Weight:
395.52
Formula:
C22H25N3O2S
Chemical Name:
2-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfanyl-5,5,7,7-tetramethyl-1H,5H,6H,7H-indeno[5,6-d]imidazol-6-one
Smiles :
CC1C(CSC2NC3=CC4=C(C=C3N=2)C(C)(C)C(=O)C4(C)C)=NC=CC=1OC
InChiKey:
RUTMNCYLHDVUCJ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25N3O2S/c1-12-17(23-8-7-18(12)27-6)11-28-20-24-15-9-13-14(10-16(15)25-20)22(4,5)19(26)21(13,2)3/h7-10H,11H2,1-6H3,(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Gimeracil Autophagy
Additional information:
Ro18-5362 is the less active prodrug of Ro 18-5364. Even at concentrations as high as 0.1 mM Ro 18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation.|Product information|CAS Number: 101387-97-7|Molecular Weight: 395.52|Formula: C22H25N3O2S|Chemical Name: 2-[(4-methoxy-3-methylpyridin-2-yl)methyl]sulfanyl-5,5,7,7-tetramethyl-1H,5H,6H,7H-indeno[5,6-d]imidazol-6-one|Smiles: CC1C(CSC2NC3=CC4=C(C=C3N=2)C(C)(C)C(=O)C4(C)C)=NC=CC=1OC|InChiKey: RUTMNCYLHDVUCJ-UHFFFAOYSA-N|InChi: InChI=1S/C22H25N3O2S/c1-12-17(23-8-7-18(12)27-6)11-28-20-24-15-9-13-14(10-16(15)25-20)22(4,5)19(26)21(13,2)3/h7-10H,11H2,1-6H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PDGF-AA Protein, Human custom synthesis |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity.PMID:33136615 Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H++K+)-ATPase activity and associated proton translocation. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H++K+)-ATPase, decreasing enzymatic activity with an apparent Ki of 0.1 μM.|References:|Sigrist-Nelson K, et al. Ro 18-5364, a potent new inhibitor of the gastric (H+ + K+)-ATPase. Eur J Biochem. 1987 Jul 15;166(2):453-9.Sigrist-Nelson K, et al. Gastric (H+ + K+)-ATPase: modulation of the inhibitory properties of the novel potent antisecretagogue Ro 18-5364 by sulfhydryl reagents and nucleotides. FEBS Lett. 1986 Mar 3;197(1-2):187-91.Products are for research use only. Not for human use.|