Product Name :
PF-04856264
Description:
PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect.
CAS:
1235397-05-3
Molecular Weight:
437.49
Formula:
C20H15N5O3S2
Chemical Name:
3-cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
Smiles :
CN1N=CC=C1C1=CC=CC=C1OC1=CC=C(C=C1C#N)S(=O)(=O)NC1=NC=CS1
InChiKey:
MKSKJVIBSRUWSZ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.{{Abciximab} medchemexpress|{Abciximab} Cytoskeleton|{Abciximab} Purity & Documentation|{Abciximab} In Vitro|{Abciximab} custom synthesis|{Abciximab} Autophagy} 7, respectively.{{Eicosatetraynoic acid} site|{Eicosatetraynoic acid} Cell Cycle/DNA Damage|{Eicosatetraynoic acid} Activator|{Eicosatetraynoic acid} Biological Activity|{Eicosatetraynoic acid} Data Sheet|{Eicosatetraynoic acid} custom synthesis} PF-04856264 has low potency against the rat Nav1.PMID:33283598 7 channel. PF-04856264 shows analgesic effect.|Product information|CAS Number: 1235397-05-3|Molecular Weight: 437.49|Formula: C20H15N5O3S2|Chemical Name: 3-cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide|Smiles: CN1N=CC=C1C1=CC=CC=C1OC1=CC=C(C=C1C#N)S(=O)(=O)NC1=NC=CS1|InChiKey: MKSKJVIBSRUWSZ-UHFFFAOYSA-N|InChi: InChI=1S/C20H15N5O3S2/c1-25-17(8-9-23-25)16-4-2-3-5-19(16)28-18-7-6-15(12-14(18)13-21)30(26,27)24-20-22-10-11-29-20/h2-12H,1H3,(H,22,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (571.44 mM; ultrasonic and warming and heat to 60°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|PF-04856264 (3-30 mg/kg; i.p.) reverses OD1-induced pain behaviors.|Products are for research use only. Not for human use.|