Product Name :
PI-828
Description:
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.
CAS:
942289-87-4
Molecular Weight:
322.36
Formula:
C19H18N2O3
Chemical Name:
8-(4-aminophenyl)-2-(morpholin-4-yl)-4H-chromen-4-one
Smiles :
NC1C=CC(=CC=1)C1=CC=CC2C(=O)C=C(OC=21)N1CCOCC1
InChiKey:
WUKMIBOGGXMBAC-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18N2O3/c20-14-6-4-13(5-7-14)15-2-1-3-16-17(22)12-18(24-19(15)16)21-8-10-23-11-9-21/h1-7,12H,8-11,20H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.|Product information|CAS Number: 942289-87-4|Molecular Weight: 322.36|Formula: C19H18N2O3|Chemical Name: 8-(4-aminophenyl)-2-(morpholin-4-yl)-4H-chromen-4-one|Smiles: NC1C=CC(=CC=1)C1=CC=CC2C(=O)C=C(OC=21)N1CCOCC1|InChiKey: WUKMIBOGGXMBAC-UHFFFAOYSA-N|InChi: InChI=1S/C19H18N2O3/c20-14-6-4-13(5-7-14)15-2-1-3-16-17(22)12-18(24-19(15)16)21-8-10-23-11-9-21/h1-7,12H,8-11,20H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.{{Ciclopirox} web|{Ciclopirox} Anti-infection|{Ciclopirox} Technical Information|{Ciclopirox} In Vivo|{Ciclopirox} custom synthesis|{Ciclopirox} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Octreotide} web|{Octreotide} Apoptosis|{Octreotide} Biological Activity|{Octreotide} In Vitro|{Octreotide} supplier|{Octreotide} Cancer} |Shelf Life: ≥360 days if stored properly.PMID:31643604 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells. PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.|References:|Zellefrow CD, et al. Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay. Radiat Res. 2012 Sep;178(3):150-9.Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21.Kulkarni AA, et al. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 1;73(23):6987-97.Products are for research use only. Not for human use.|