Product Name :
Malantide TFA
Description:
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM.
CAS:
Molecular Weight:
1747.91
Formula:
C74H125F3N22O23
Chemical Name:
(6S, 9S, 12S, 15S, 18S, 24S, 27S, 30S, 33S)-1, 1, 6-triamino-33-((S)-2-(((S)-1-(((S)-6-amino-1-(((1S, 2S)-1-carboxy-2-methylbutyl)amino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-12-(4-aminobutyl)-15-(3-((diaminomethylene)amino)propyl)-30-(4-hydroxybenzyl)-9-((R)-1-hydroxyethyl)-18, 24-bis(hydroxymethyl)-27-isopropyl-7, 10, 13, 16, 19, 22, 25, 28, 31-nonaoxo-2, 8, 11, 14, 17, 20, 23, 26, 29, 32-decaazahexatriacont-1-en-36-oic acid–2, 2, 2-trifluoroacetic acid (1/1)
Smiles :
CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(N)CCCN=C(N)N)C(C)O)C(C)C)C(O)=O.OC(=O)C(F)(F)F
InChiKey:
XXWDVGVMTSROQS-UHFFFAOYSA-N
InChi :
InChI=1S/C72H124N22O21.C2HF3O2/c1-8-39(6)56(70(114)115)92-62(106)45(18-10-12-28-74)85-63(107)48(32-37(2)3)88-66(110)52-20-15-31-94(52)69(113)47(25-26-54(100)101)87-64(108)49(33-41-21-23-42(98)24-22-41)89-67(111)55(38(4)5)91-65(109)51(36-96)83-53(99)34-82-59(103)50(35-95)90-61(105)46(19-14-30-81-72(78)79)84-60(104)44(17-9-11-27-73)86-68(112)57(40(7)97)93-58(102)43(75)16-13-29-80-71(76)77;3-2(4,5)1(6)7/h21-24,37-40,43-52,55-57,95-98H,8-20,25-36,73-75H2,1-7H3,(H,82,103)(H,83,99)(H,84,104)(H,85,107)(H,86,112)(H,87,108)(H,88,110)(H,89,111)(H,90,105)(H,91,109)(H,92,106)(H,93,102)(H,100,101)(H,114,115)(H4,76,77,80)(H4,78,79,81);(H,6,7)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a Km of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts. Malantide TFA is also an efficient substrate for PKC with a Km of 16 μM.|Product information|Molecular Weight: 1747.91|Formula: C74H125F3N22O23|Chemical Name: (6S, 9S, 12S, 15S, 18S, 24S, 27S, 30S, 33S)-1, 1, 6-triamino-33-((S)-2-(((S)-1-(((S)-6-amino-1-(((1S, 2S)-1-carboxy-2-methylbutyl)amino)-1-oxohexan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-12-(4-aminobutyl)-15-(3-((diaminomethylene)amino)propyl)-30-(4-hydroxybenzyl)-9-((R)-1-hydroxyethyl)-18, 24-bis(hydroxymethyl)-27-isopropyl-7, 10, 13, 16, 19, 22, 25, 28, 31-nonaoxo-2, 8, 11, 14, 17, 20, 23, 26, 29, 32-decaazahexatriacont-1-en-36-oic acid–2, 2, 2-trifluoroacetic acid (1/1)|Smiles: CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CO)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(N)CCCN=C(N)N)C(C)O)C(C)C)C(O)=O.{{Buspirone} medchemexpress|{Buspirone} Reactive Oxygen Species|{Buspirone} Biological Activity|{Buspirone} In Vivo|{Buspirone} manufacturer|{Buspirone} Epigenetics} OC(=O)C(F)(F)F|InChiKey: XXWDVGVMTSROQS-UHFFFAOYSA-N|InChi: InChI=1S/C72H124N22O21.{{Ociperlimab} medchemexpress|{Ociperlimab} Purity & Documentation|{Ociperlimab} Formula|{Ociperlimab} supplier|{Ociperlimab} Autophagy} C2HF3O2/c1-8-39(6)56(70(114)115)92-62(106)45(18-10-12-28-74)85-63(107)48(32-37(2)3)88-66(110)52-20-15-31-94(52)69(113)47(25-26-54(100)101)87-64(108)49(33-41-21-23-42(98)24-22-41)89-67(111)55(38(4)5)91-65(109)51(36-96)83-53(99)34-82-59(103)50(35-95)90-61(105)46(19-14-30-81-72(78)79)84-60(104)44(17-9-11-27-73)86-68(112)57(40(7)97)93-58(102)43(75)16-13-29-80-71(76)77;3-2(4,5)1(6)7/h21-24,37-40,43-52,55-57,95-98H,8-20,25-36,73-75H2,1-7H3,(H,82,103)(H,83,99)(H,84,104)(H,85,107)(H,86,112)(H,87,108)(H,88,110)(H,89,111)(H,90,105)(H,91,109)(H,92,106)(H,93,102)(H,100,101)(H,114,115)(H4,76,77,80)(H4,78,79,81);(H,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33342260 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|K J Murray, et al. Use of a Synthetic Dodecapeptide (Malantide) to Measure the Cyclic AMP-dependent Protein Kinase Activity Ratio in a Variety of Tissues. Biochem J. 1990 May 1;267(3):703-8.Products are for research use only. Not for human use.|