Product Name :
NNC45-0781
Description:
NNC45-0781 is a tissue-selective estrogen partial-agonist.
CAS:
207277-66-5
Molecular Weight:
415.52
Formula:
C27H29NO3
Chemical Name:
(3S,4R)-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol
Smiles :
OC1C=C2OC[C@@H]([C@@H](C2=CC=1)C1C=CC(=CC=1)OCCN1CCCC1)C1C=CC=CC=1
InChiKey:
FEVZKAOFFCUDLI-XNMGPUDCSA-N
InChi :
InChI=1S/C27H29NO3/c29-22-10-13-24-26(18-22)31-19-25(20-6-2-1-3-7-20)27(24)21-8-11-23(12-9-21)30-17-16-28-14-4-5-15-28/h1-3,6-13,18,25,27,29H,4-5,14-17,19H2/t25-,27-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{CITCO} MedChemExpress|{CITCO} Inducer|{CITCO} Immunology/Inflammation|{CITCO} Biological Activity|{CITCO} In Vivo|{CITCO} custom synthesis}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NNC45-0781 is a tissue-selective estrogen partial-agonist.{{6-Mercaptopurine} medchemexpress|{6-Mercaptopurine} Metabolic Enzyme/Protease|{6-Mercaptopurine} Technical Information|{6-Mercaptopurine} Description|{6-Mercaptopurine} custom synthesis|{6-Mercaptopurine} Epigenetics} |Product information|CAS Number: 207277-66-5|Molecular Weight: 415.PMID:32298226 52|Formula: C27H29NO3|Chemical Name: (3S,4R)-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol|Smiles: OC1C=C2OC[C@@H]([C@@H](C2=CC=1)C1C=CC(=CC=1)OCCN1CCCC1)C1C=CC=CC=1|InChiKey: FEVZKAOFFCUDLI-XNMGPUDCSA-N|InChi: InChI=1S/C27H29NO3/c29-22-10-13-24-26(18-22)31-19-25(20-6-2-1-3-7-20)27(24)21-8-11-23(12-9-21)30-17-16-28-14-4-5-15-28/h1-3,6-13,18,25,27,29H,4-5,14-17,19H2/t25-,27-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group.|Products are for research use only. Not for human use.|