Product Name :
MAC glucuronide phenol-linked SN-38
Description:
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.
CAS:
2246380-69-6
Molecular Weight:
1091.06
Formula:
C50H54N6O20S
Chemical Name:
(2S, 3S, 4S, 5R, 6S)-6-[4-({[({[(19S)-10, 19-diethyl-19-hydroxy-14, 18-dioxo-17-oxa-3, 13-diazapentacyclo[11.8.0.0, .0, .0, ]henicosa-1(21), 2, 4(9), 5, 7, 10, 15(20)-heptaen-7-yl]oxy}methyl)(2-methanesulfonylethyl)carbamoyl]oxy}methyl)-2-{2-[3-(2, 5-dioxo-2, 5-dihydro-1H-pyrrol-1-yl)-N-methylpropanamido]acetamido}phenoxy]-3, 4, 5-trihydroxyoxane-2-carboxylic acid
Smiles :
CN(CC(=O)NC1=CC(COC(=O)N(COC2=CC3=C(C=C2)N=C2C4=CC5=C(COC(=O)[C@]5(O)CC)C(=O)N4CC2=C3CC)CCS(C)(=O)=O)=CC=C1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(=O)CCN1C(=O)C=CC1=O
InChiKey:
IKQSTTAUHYHYCV-GVAVQZEZSA-N
InChi :
InChI=1S/C50H54N6O20S/c1-5-27-28-18-26(8-9-32(28)52-40-29(27)20-56-34(40)19-31-30(45(56)64)23-72-48(67)50(31,69)6-2)74-24-54(15-16-77(4,70)71)49(68)73-22-25-7-10-35(75-47-43(63)41(61)42(62)44(76-47)46(65)66)33(17-25)51-36(57)21-53(3)37(58)13-14-55-38(59)11-12-39(55)60/h7-12,17-19,41-44,47,61-63,69H,5-6,13-16,20-24H2,1-4H3,(H,51,57)(H,65,66)/t41-,42-,43+,44-,47+,50-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Opaganib} web|{Opaganib} SphK|{Opaganib} Protocol|{Opaganib} Description|{Opaganib} supplier|{Opaganib} Cancer}
Shelf Life:
≥12 months if stored properly.{{Methimazole} MedChemExpress|{Methimazole} Technical Information|{Methimazole} Formula|{Methimazole} custom synthesis|{Methimazole} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24423657
Additional information:
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.|Product information|CAS Number: 2246380-69-6|Molecular Weight: 1091.06|Formula: C50H54N6O20S|Chemical Name: (2S, 3S, 4S, 5R, 6S)-6-[4-({[({[(19S)-10, 19-diethyl-19-hydroxy-14, 18-dioxo-17-oxa-3, 13-diazapentacyclo[11.8.0.0, .0, .0, ]henicosa-1(21), 2, 4(9), 5, 7, 10, 15(20)-heptaen-7-yl]oxy}methyl)(2-methanesulfonylethyl)carbamoyl]oxy}methyl)-2-{2-[3-(2, 5-dioxo-2, 5-dihydro-1H-pyrrol-1-yl)-N-methylpropanamido]acetamido}phenoxy]-3, 4, 5-trihydroxyoxane-2-carboxylic acid|Smiles: CN(CC(=O)NC1=CC(COC(=O)N(COC2=CC3=C(C=C2)N=C2C4=CC5=C(COC(=O)[C@]5(O)CC)C(=O)N4CC2=C3CC)CCS(C)(=O)=O)=CC=C1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(=O)CCN1C(=O)C=CC1=O|InChiKey: IKQSTTAUHYHYCV-GVAVQZEZSA-N|InChi: InChI=1S/C50H54N6O20S/c1-5-27-28-18-26(8-9-32(28)52-40-29(27)20-56-34(40)19-31-30(45(56)64)23-72-48(67)50(31,69)6-2)74-24-54(15-16-77(4,70)71)49(68)73-22-25-7-10-35(75-47-43(63)41(61)42(62)44(76-47)46(65)66)33(17-25)51-36(57)21-53(3)37(58)13-14-55-38(59)11-12-39(55)60/h7-12,17-19,41-44,47,61-63,69H,5-6,13-16,20-24H2,1-4H3,(H,51,57)(H,65,66)/t41-,42-,43+,44-,47+,50-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (183.31 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|