Product Name :
Indomethacin sodium hydrate
Description:
Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin sodium hydrate disrupts autophagic flux by disturbing the normal functioning of lysosomes.
CAS:
74252-25-8
Molecular Weight:
433.82
Formula:
C19H21ClNNaO7
Chemical Name:
sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate trihydrate
Smiles :
O.O.O.CC1=C(CC(=O)O[Na])C2C=C(C=CC=2N1C(=O)C1C=CC(Cl)=CC=1)OC
InChiKey:
UHYAQBLOGVNWNT-UHFFFAOYSA-M
InChi :
InChI=1S/C19H16ClNO4.Na.3H2O/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;;;;/h3-9H,10H2,1-2H3,(H,22,23);;3*1H2/q;+1;;;/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.{{Osilodrostat} MedChemExpress|{Osilodrostat} Vitamin D Related/Nuclear Receptor|{Osilodrostat} Protocol|{Osilodrostat} In Vivo|{Osilodrostat} custom synthesis|{Osilodrostat} Epigenetic Reader Domain} Indomethacin sodium hydrate disrupts autophagic flux by disturbing the normal functioning of lysosomes.{{Rapamycin} web|{Rapamycin} Anti-infection|{Rapamycin} Technical Information|{Rapamycin} In stock|{Rapamycin} manufacturer|{Rapamycin} Epigenetics} |Product information|CAS Number: 74252-25-8|Molecular Weight: 433.PMID:23667820 82|Formula: C19H21ClNNaO7|Chemical Name: sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate trihydrate|Smiles: O.O.O.CC1=C(CC(=O)O[Na])C2C=C(C=CC=2N1C(=O)C1C=CC(Cl)=CC=1)OC|InChiKey: UHYAQBLOGVNWNT-UHFFFAOYSA-M|InChi: InChI=1S/C19H16ClNO4.Na.3H2O/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;;;;/h3-9H,10H2,1-2H3,(H,22,23);;3*1H2/q;+1;;;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (11.53 mM; Need ultrasonic). H2O : 33.33 mg/mL (76.83 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin inhibits lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC50=0.68±0.17 μM), and suppresses coagulation-induced TXB2 production (COX-1) (IC50=0.19±0.02 μM). Indomethacin blocks COX-1 with an IC50 of 20±1 nM in U937 cell microsomes at a low arachidonic acid concentration (0.1 μM).|In Vivo:|Indomethacin dose-dependently inhibits both the carrageenan-induced rat paw oedema (ED50, 2.0 mg/kg), hyperalgesia (ED50, 1.5 mg/kg), and is also effective at reversing LPS-induced pyrexia in rats (ED50, 1.1 mg/kg). Indomethacin (2.5 mg/kg, i.p) decreases the number of NeuN+ cells in the animals at 8 days after ET-1 injection. Indomethacin also reduces microglia/macrophage activation at 14 days. Indomethacin significantly increases the number of SVZ DCX+ cells/field at 14 days post stroke. Indomethacin (22.9 mg/kg, p.o.) produces 8 to 10 linear mucosal lesions extended from the fundic to pyloric area of stomach wall.|Products are for research use only. Not for human use.|