Product Name :
Puromycin aminonucleoside
Description:
Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.
CAS:
58-60-6
Molecular Weight:
294.31
Formula:
C12H18N6O3
Chemical Name:
(2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol
Smiles :
CN(C)C1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O
InChiKey:
RYSMHWILUNYBFW-GRIPGOBMSA-N
InChi :
InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{GLP-1(7-36), amide} site|{GLP-1(7-36), amide} GPCR/G Protein|{GLP-1(7-36), amide} Immunology/Inflammation|{GLP-1(7-36), amide} Biological Activity|{GLP-1(7-36), amide} In Vitro|{GLP-1(7-36), amide} supplier}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Corn oil} site|{Corn oil} {Biochemical Assay Reagents}|{Corn oil} Protocol|{Corn oil} In Vivo|{Corn oil} custom synthesis|{Corn oil} Epigenetic Reader Domain}
Additional information:
Puromycin aminonucleoside (NSC 3056, PAN, Stylomycin aminonucleoside, ARDMA, SAN), the aminonucleoside portion of the antibiotic puromycin, is a reversible inhibitor of dipeptidyl-peptidase II and cytosol alanyl aminopeptidase that induces apoptosis in mesangial cells (MCs) accompanied by declined cell viability and enhanced inflammatory response.PMID:23439434 |Product information|CAS Number: 58-60-6|Molecular Weight: 294.31|Formula: C12H18N6O3|Synonym:|ARDMA|NSC 3056|SAN|Stylomycin aminonucleoside|Chemical Name: (2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol|Smiles: CN(C)C1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O|InChiKey: RYSMHWILUNYBFW-GRIPGOBMSA-N|InChi: InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 59 mg/mL(200.46 mM). Water: 30 mg/mL(101.93 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Puromycin aminonucleoside (PAN) induces MC apoptosis accompanied by the declined cell viability and enhanced inflammatory response. In PAN-treated MCs, ERRα overexpression further aggravates PAN-induced apoptosis.|In Vivo:|In agreement with the in vitro study, increased ERRα expression is observed in line with enhanced apoptotic response in renal cortex from PAN-treated rats.|References:|Wei Gong, et al. Am J Physiol Renal Physiol. 2019 May 1;316(5):F906-F913.Products are for research use only. Not for human use.|