Product Name :
PF-04995274
Description:
PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer’s disease.
CAS:
1331782-27-4
Molecular Weight:
432.51
Formula:
C23H32N2O6
Chemical Name:
(R)-4-((4-(((4-(Tetrahydrofuran-3-yloxy)-1,2-benzisoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol
Smiles :
OC1(CN2CCC(COC3=NOC4=CC=CC(O[C@H]5COCC5)=C43)CC2)CCOCC1
InChiKey:
WLLOFQROROXOMO-GOSISDBHSA-N
InChi :
InChI=1S/C23H32N2O6/c26-23(7-12-27-13-8-23)16-25-9-4-17(5-10-25)14-29-22-21-19(30-18-6-11-28-15-18)2-1-3-20(21)31-24-22/h1-3,17-18,26H,4-16H2/t18-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer’s disease.|Product information|CAS Number: 1331782-27-4|Molecular Weight: 432.{{Bupivacaine} web|{Bupivacaine} Sodium Channel|{Bupivacaine} Protocol|{Bupivacaine} Description|{Bupivacaine} manufacturer|{Bupivacaine} Autophagy} 51|Formula: C23H32N2O6|Synonym:|PF 04995274|PF04995274|PF-4995274|PF 4995274|PF4995274|Chemical Name: (R)-4-((4-(((4-(Tetrahydrofuran-3-yloxy)-1,2-benzisoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol|Smiles: OC1(CN2CCC(COC3=NOC4=CC=CC(O[C@H]5COCC5)=C43)CC2)CCOCC1|InChiKey: WLLOFQROROXOMO-GOSISDBHSA-N|InChi: InChI=1S/C23H32N2O6/c26-23(7-12-27-13-8-23)16-25-9-4-17(5-10-25)14-29-22-21-19(30-18-6-11-28-15-18)2-1-3-20(21)31-24-22/h1-3,17-18,26H,4-16H2/t18-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 86 mg/mL(198.{{Amlodipine} site|{Amlodipine} Neuronal Signaling|{Amlodipine} Protocol|{Amlodipine} Data Sheet|{Amlodipine} supplier|{Amlodipine} Autophagy} 83 mM).PMID:35126464 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Timothy Nicholas, et al. Advances in Alzheimer’s Disease. Vol.2 No.3(2013), Article ID:37276,16 pages.Products are for research use only. Not for human use.|