Product Name :
AZ1495

Description:
AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).

CAS:
2196204-23-4

Molecular Weight:
385.50

Formula:
C21H31N5O2

Chemical Name:
5-(oxan-4-yl)-N-[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Smiles :
C1C[C@H](CC[C@@H]1N1CCOCC1)NC1=NC=NC2NC=C(C3CCOCC3)C=21

InChiKey:
DJVYXMINSBMUHH-QAQDUYKDSA-N

InChi :
InChI=1S/C21H31N5O2/c1-3-17(26-7-11-28-12-8-26)4-2-16(1)25-21-19-18(15-5-9-27-10-6-15)13-22-20(19)23-14-24-21/h13-17H,1-12H2,(H2,22,23,24,25)/t16-,17-

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rucaparib} medchemexpress|{Rucaparib} PARP|{Rucaparib} Biological Activity|{Rucaparib} Description|{Rucaparib} manufacturer|{Rucaparib} Autophagy}

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Gemifloxacin} MedChemExpress|{Gemifloxacin} Cell Cycle/DNA Damage|{Gemifloxacin} Technical Information|{Gemifloxacin} In Vivo|{Gemifloxacin} manufacturer|{Gemifloxacin} Epigenetics}

Additional information:
AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).PMID:23558135 |Product information|CAS Number: 2196204-23-4|Molecular Weight: 385.50|Formula: C21H31N5O2|Chemical Name: 5-(oxan-4-yl)-N-[(1r,4r)-4-(morpholin-4-yl)cyclohexyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine|Smiles: C1C[C@H](CC[C@@H]1N1CCOCC1)NC1=NC=NC2NC=C(C3CCOCC3)C=21|InChiKey: DJVYXMINSBMUHH-QAQDUYKDSA-N|InChi: InChI=1S/C21H31N5O2/c1-3-17(26-7-11-28-12-8-26)4-2-16(1)25-21-19-18(15-5-9-27-10-6-15)13-22-20(19)23-14-24-21/h13-17H,1-12H2,(H2,22,23,24,25)/t16-,17-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 10 mg/mL (25.94 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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