, the soil’s pH declined though its salinity (EC) rose, indicating that the soil became more saline (EC = 6.45 S cm-1) and somewhat acidic (six.8). Low pH and higher salinity enhance the availability, mobility, and redistribution of heavy metals in diverse soil fractions (Ahmed et al. 2022). The current study found that irrigation with wastewater enhanced the levels of nutrients and heavy metals. According to Slima and Ahmed (2020), the enhance in nutrient concentrations in polluted soil might be the outcome of absorption competitors with accessible heavy metals, which becameEnvironmental Science and Pollution Analysis (2023) 30:42255Table 7 Daily intake rate (DIR) and hazard quotient (HQ) of heavy metals in tomato fruits watered with untreated wastewater (contaminated farms) and Nile water (uncontaminated farms). A: adult, C: youngsters, and RfD: reference dose of trace metals. Values 1 are in bold Heavy metal Contaminated farms DIR (mg day-1) A Pb Cd Cr Cu Ni Fe Mn Zn Co 2.0738 0.5740 0.0044 0.0036 0.0094 28.7500 2.0489 0.3431 0.0139 C 2.5589 0.7083 0.0054 0.0044 0.0116 35.4740 two.5281 0.4233 0.0171 HQ A 2073.8333 574.0417 0.0029 0.0898 0.4696 41.0714 146.3512 1.1436 0.3232 C 2558.8583 708.2977 0.0036 0.1109 0.5794 50.6772 180.5796 1.4111 0.3987 Uncontaminated farms DIR (mg day-1) A 0.6525 0.7576 0.0086 0.0076 0.0179 1.6593 0.6598 0.1515 0.0288 C 0.4388 0.5094 0.0058 0.0051 0.0120 1.1158 0.4437 0.1019 0.0194 HQ A 652.4813 757.5625 0.0057 0.1894 0.8932 two.3704 47.1295 0.5050 0.6695 C 438.7700 509.4333 0.0038 0.1274 0.6006 1.5940 31.6929 0.3396 0.4502 0.0010 0.0010 1.5000 0.0400 0.0200 0.7000 0.0140 0.3000 0.0430 (US-EPA 2013) (US-EPA 2013) (US-EPA 2013) (FAO/WHO 2013) (US-EPA 2010) (FAO/WHO 2013) (FAO/WHO 2013) (FAO/WHO 2013) (US-EPA 2013) RfD
ONCOLOGY LETTERS 6: 748-752,Inhibition of hepatocellular carcinoma development by adenovirusmediated expression of human telomerase reverse transcriptase COOH27 terminal polypeptide in miceLEI HE1*, HAN-XIAN GONG1*, XIANG-PEN LI1, YI-DONG WANG1, YI LI1, JUN-JIAN HUANG2, DAN XIE3, HSIANG-FU KUNG4 and YING PENGDepartment of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120; two Laboratory of Tumor and Molecular Biology, Beijing Institute of Biotechnology, Beijing 100071; 3 State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510120; 4Stanley Ho Center for Emerging Infectious Illnesses, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, P.Octreotide R.Oxytocin China Received January ten, 2013; Accepted July 1, 2013 DOI: 10.PMID:32472497 3892/ol.2013.Abstract. A 27-kDa C-terminal fragment of human telomerase reverse transcriptase, hTERTC27, has previously been reported to inhibit the growth and tumorigenicity of HeLa human cervical cancer cells and U87-MG human glioblastoma multiforme cells. On the other hand, the antitumor effects of hTERTC27 in hepatoma and its underlying mechanisms are unclear. Within the present study, the therapeutic impact of hTERTC27, mediated by recombinant adenovirus, in hepatocellular carcinoma (HCC) was explored in vitro and in vivo to investigate the achievable mechanisms. The outcomes indicated that recombinant adenovirus carrying hTERTC27 (rAdv-hTERTC27) successfully inhibited the development and induced apoptosis on the Hepa 1-6 HCC cells. Dendritic cells transduced with rAdv-hTERTC27 have been hugely helpful at inducing antigenspecific T cell proliferation and rising the activated cytotoxicity of T cells against Hepa 1-6 cells. H.