TIONCorresponding Author*Tel: 301 496 1765. Fax: 301 402 0074. E-mail: [email protected]. gov.FundingThis operate was completely supported by the Intramural Program of the National Institute on Aging.NotesThe authors declare no competing monetary interest.dx.doi.org/10.1021/cn500058v | ACS Chem. Neurosci. 2014, five, 459-ACS Chemical NeuroscienceReviewACKNOWLEDGMENTS I am indebted to Drs. Chuck T. Chen and Erika F. H. Saunders also as Mr. Christopher T. Primiani and Ms. Veronica H. Ryan for their pretty valuable comments and suggestions. ABBREVIATIONS AA, arachidonic acid; AMPA, alpha-amino-3-hydroxy-5-methyl4-isoxazolepropionic acid; AP, activator protein; Bad, Bcl-2 related death promoter; BAX, Bcl-2-associated X protein; BD, bipolar disorder; BDNF, brain derived neurotrophic issue; Bcl2, B-cell lymphoma-2; COX, cyclooxygenase; CSF, cerebrospinal fluid; CYP450, cytochrome P450 epoxygenase; DAT, dopamine reuptake transporter; DHA, docosahexaenoic acid; DOI, (-1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride; EAAT, excitatory amino acid (reuptake) transporter; GFAP, glial fibrillary acidic protein; GRK, G-protein receptor kinase; GSK, glycogen synthase kinase; 5-HT, 5-hydroxytryptamine (serotonin); IL-1, interleukin-1; IL-1R, interleukin receptor; IMPase, inositol monophosphatase; iNOS, inducible nitric oxide synthase; LPCAT, lysophospholipid acyltransferase; LOX, lipoxygenase; LTB4, leukotriene B4; m-PGES-2, membrane PGE synthase-2; NMDA, N-methyl-D-aspartic acid; NF-B, nuclear element kappa B; NR, NMDA receptor; PET, positron emission tomography; PGE2, prostaglandin E2; PLA2, phospholipase A2; cPLA2, cytosolic PLA2; iPLA2, calcium independent PLA2; sPLA2, secretory PLA2; PUFA, polyunsaturated fatty acid; sn, stereospecifically numbered; SSRI, selective serotonin reuptake inhibitor; TNF, tumor necrosis aspect alpha; TXS, thromboxane synthase(1) (a) Rapoport, S. I., Basselin, M., Kim, H. W., and Rao, J. S. (2009) Bipolar disorder and mechanisms of action of mood stabilizers. Brain Res. Rev. 61 (two), 185-209. (b) Goodwin, F. K., and Jamison, K. R. (2007) Manic-Depressive Illness: Bipolar Problems and Recurrent Depression, 2nd ed., p 1262, Oxford University Press, New York. (2) (a) Post, R. M., Jimerson, D. C., Bunney, W. E., Jr., and Goodwin, F. K. (1980) Dopamine and mania: behavioral and biochemical effects on the dopamine receptor blocker pimozide.Glatiramer acetate Psychopharmacology (Berlin, Ger.Cephalexin monohydrate ) 67 (3), 297-305.PMID:28630660 (b) Janowsky, D. S., and Overstreet, D. H. (1995) The role of acetylcholine mechanisms in mood issues. In Psychopharmacology. The Fourth Generation of Progress (Bloom. F. E., and Kupfer D. J., Eds.), pp 945-956, Raven, New York. (3) Tamminga, C. A. (2013) Validating psychosis biotypes. ACNP J. 38 (S2), 22.4. (four) Baum, A. E., Akula, N., Cabanero, M., Cardona, I., Corona, W., Klemens, B., Schulze, T. G., Cichon, S., Rietschel, M., Nothen, M. M., Georgi, A., Schumacher, J., Schwarz, M., Abou Jamra, R., Hofels, S., Propping, P., Satagopan, J., Detera-Wadleigh, S. D., Hardy, J., and McMahon, F. J. (2008) A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and many other genes in the etiology of bipolar disorder. Mol. Psychiatry 13 (2), 197-207. (5) Cade, J. F. J. (1949) Lithium salts in the remedy of psychotic excitement. Med. J. Aust. 36, 349-352. (six) Berridge, M. J. (1989) The Albert Lasker Healthcare Awards. Inositol trisphosphate, calcium, lithium, and cell signaling. JAMA, J. Am. Med. Assoc. 262 (13), 1834-184.