Lay antioxidant, phospholipids, and betaine lipids, hold the potential to display antioxidant, anti-inflammatory antiinflammatory and antimicrobial properties [6,7]. Glycolipids are important components of and antimicrobial properties [6,7]. Glycolipids are important components of plants being mostly plants being mostly located been demonstrated to display anti-inflammatory, antibacterial, and located in chloroplasts and have in chloroplasts and have been demonstrated to display anti inflammatory, antibacterial, and antiviral activity [8]. Furthermore, phospholipid molecules, known antiviral activity [8]. Furthermore, phospholipid molecules, known to be universal components of to be universal components of the lipid bilayer of cell membranes, such as Stattic web phosphatidylcholine (PC), the lipid bilayer of cell membranes, such as phosphatidylcholine (PC), phosphatidylglycerols (PG), phosphatidylglycerols (PG), phosphatidylethanolamines (PE), and phosphatydylserines (PS`s), phosphatidylethanolamines (PE), and phosphatydylserines (PS’s), possess nutraceutical relevance. possess nutraceutical relevance. By being carriers of polyunsaturated fatty acids (PUFAs), they have By beingpotential to be used as a valuable ingredient (PUFAs), they have the potential to be and as the carriers of polyunsaturated fatty acids in functional foods, as well as in cosmetic used a valuable ingredient in functional foods, as well as in cosmetic and pharmaceutical industries. pharmaceutical industries.Mar. Drugs 2016, 14, x2 ofFigure 1. Marine macrophytes: (A) Ulva lactuca (green macroalgae); (B) Zostera noltii (seagrass); (C) Figure 1. Marine macrophytes: (A) Ulva lactuca (green macroalgae); (B) Zostera noltii (seagrass); Salicornia ramosissima (halophyte PD173074 site nonseagrass); (D) Aster tripolium (halophyte nonseagrass); and (E) (C) Salicornia ramosissima (halophyte non-seagrass); (D) Aster tripolium (halophyte non-seagrass); and Halimione portulacoides (halophyte nonseagrass). Images (A,C,D) by Ana I. Lilleb? (B) by Ana. I. (E) Halimione portulacoides (halophyte non-seagrass). Images (A,C,D) by Ana I. Lilleb? (B) by Ana. I. Sousa; and (E) by Bruna Marques. Sousa; and (E) by Bruna Marques.The lipid composition of marine macrophytes can shift as an adaptive response to changes in environmental and/or physiological conditions [9]. This ability can be used to manipulate growth The lipid composition of marine macrophytes can shift as an adaptive response to changes in conditions and obtain the most desired lipid [9]. This ability fatty acid (FA) profile of some environmental and/or physiological conditionsprofile. While the can be used to manipulate growth macrophytes has been previously described [10,11], their total lipidome is still poorly investigated. conditions and obtain the most desired lipid profile. While the fatty acid (FA) profile of some This gap of knowledge may be due to the complexity of this topic, as the lipidome comprises several macrophytes has been previously described [10,11], their total lipidome is still poorly investigated. distinct classes of lipids, such as triglycerides, sterols, phospholipids, glycolipids, among others. In This gap of knowledge may be due to the complexity of this topic, as the lipidome comprises several order to truly unravel the lipidome of marine macrophytes, it is essential to employ stateoftheart distinct classes of lipids, such as triglycerides,.Lay antioxidant, phospholipids, and betaine lipids, hold the potential to display antioxidant, anti-inflammatory antiinflammatory and antimicrobial properties [6,7]. Glycolipids are important components of and antimicrobial properties [6,7]. Glycolipids are important components of plants being mostly plants being mostly located been demonstrated to display anti-inflammatory, antibacterial, and located in chloroplasts and have in chloroplasts and have been demonstrated to display anti inflammatory, antibacterial, and antiviral activity [8]. Furthermore, phospholipid molecules, known antiviral activity [8]. Furthermore, phospholipid molecules, known to be universal components of to be universal components of the lipid bilayer of cell membranes, such as phosphatidylcholine (PC), the lipid bilayer of cell membranes, such as phosphatidylcholine (PC), phosphatidylglycerols (PG), phosphatidylglycerols (PG), phosphatidylethanolamines (PE), and phosphatydylserines (PS`s), phosphatidylethanolamines (PE), and phosphatydylserines (PS’s), possess nutraceutical relevance. possess nutraceutical relevance. By being carriers of polyunsaturated fatty acids (PUFAs), they have By beingpotential to be used as a valuable ingredient (PUFAs), they have the potential to be and as the carriers of polyunsaturated fatty acids in functional foods, as well as in cosmetic used a valuable ingredient in functional foods, as well as in cosmetic and pharmaceutical industries. pharmaceutical industries.Mar. Drugs 2016, 14, x2 ofFigure 1. Marine macrophytes: (A) Ulva lactuca (green macroalgae); (B) Zostera noltii (seagrass); (C) Figure 1. Marine macrophytes: (A) Ulva lactuca (green macroalgae); (B) Zostera noltii (seagrass); Salicornia ramosissima (halophyte nonseagrass); (D) Aster tripolium (halophyte nonseagrass); and (E) (C) Salicornia ramosissima (halophyte non-seagrass); (D) Aster tripolium (halophyte non-seagrass); and Halimione portulacoides (halophyte nonseagrass). Images (A,C,D) by Ana I. Lilleb? (B) by Ana. I. (E) Halimione portulacoides (halophyte non-seagrass). Images (A,C,D) by Ana I. Lilleb? (B) by Ana. I. Sousa; and (E) by Bruna Marques. Sousa; and (E) by Bruna Marques.The lipid composition of marine macrophytes can shift as an adaptive response to changes in environmental and/or physiological conditions [9]. This ability can be used to manipulate growth The lipid composition of marine macrophytes can shift as an adaptive response to changes in conditions and obtain the most desired lipid [9]. This ability fatty acid (FA) profile of some environmental and/or physiological conditionsprofile. While the can be used to manipulate growth macrophytes has been previously described [10,11], their total lipidome is still poorly investigated. conditions and obtain the most desired lipid profile. While the fatty acid (FA) profile of some This gap of knowledge may be due to the complexity of this topic, as the lipidome comprises several macrophytes has been previously described [10,11], their total lipidome is still poorly investigated. distinct classes of lipids, such as triglycerides, sterols, phospholipids, glycolipids, among others. In This gap of knowledge may be due to the complexity of this topic, as the lipidome comprises several order to truly unravel the lipidome of marine macrophytes, it is essential to employ stateoftheart distinct classes of lipids, such as triglycerides,.