Product Name :
2, 4-Pyridinedicarboxylic Acid
Description:
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases . Histone lysine-specific demethylases JMJD2A (KDM4A) and KDM4C are both members of the Jumonji domain 2 (JMJD2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. KDM5B is an H3K4me3⁄ me2-specific lysine demethylase . 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of JMJD2A (KDM4A), KDM4C and KDM5B. In the FDH-coupled assay, 2,4-PDCA inhibited ccKDM5B with IC50 value of 3 ± 1 μM. In MALDI-TOF analysis of H3(1-21)K4me3, 2,4-PDCA reduced the level of H3(1-15) induced by ccKDM5B. In U2-OS cells transfected with KDM5B, 2,4-PDCA inhibited the decrease of H3K4me3 . In HG-treated VSMCs, 2,4-PDCA (1.0 mM) inhibited JMJD2A and HG-induced proliferation in a concentration-dependent way, and inhibited HG-induced migration. 2,4-PDCA also reduced the mRNA and protein levels of MCP-1 and IL-6 . In diabetic rats, 2,4-PDCA (7.5 mg/kg/d) reduced neointimal area and I/M ratio in the injured arteries 28 days after injury. 2,4-PDCA also inhibited the percentage of PCNA-positive cells in the neointima .
CAS:
499-80-9
Formula:
C7H5NO4
Chemical Name:
pyridine-2,4-dicarboxylic acid
Smiles :
OC(=O)C1C=C(C=CN=1)C(O)=O
InChiKey:
MJIVRKPEXXHNJT-UHFFFAOYSA-N
InChi :
InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sarolaner} site|{Sarolaner} Anti-infection|{Sarolaner} Protocol|{Sarolaner} References|{Sarolaner} manufacturer|{Sarolaner} Autophagy}
Shelf Life:
≥12 months if stored properly.PMID:23453497
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases . Histone lysine-specific demethylases JMJD2A (KDM4A) and KDM4C are both members of the Jumonji domain 2 (JMJD2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. KDM5B is an H3K4me3⁄ me2-specific lysine demethylase . 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of JMJD2A (KDM4A), KDM4C and KDM5B. In the FDH-coupled assay, 2,4-PDCA inhibited ccKDM5B with IC50 value of 3 ± 1 μM. In MALDI-TOF analysis of H3(1-21)K4me3, 2,4-PDCA reduced the level of H3(1-15) induced by ccKDM5B. In U2-OS cells transfected with KDM5B, 2,4-PDCA inhibited the decrease of H3K4me3 . In HG-treated VSMCs, 2,4-PDCA (1.0 mM) inhibited JMJD2A and HG-induced proliferation in a concentration-dependent way, and inhibited HG-induced migration. 2,4-PDCA also reduced the mRNA and protein levels of MCP-1 and IL-6 . In diabetic rats, 2,4-PDCA (7.5 mg/kg/d) reduced neointimal area and I/M ratio in the injured arteries 28 days after injury. 2,4-PDCA also inhibited the percentage of PCNA-positive cells in the neointima .|Product information|CAS Number: 499-80-9|Molecular Weight: 167.12|Formula: C7H5NO4|Chemical Name: pyridine-2,4-dicarboxylic acid|Smiles: OC(=O)C1C=C(C=CN=1)C(O)=O|InChiKey: MJIVRKPEXXHNJT-UHFFFAOYSA-N|InChi: InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|