Idines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys. J. 2011, 101, L41 43. 43. Rodnin, M.V.; Posokhov, Y.O.; Contino-Pepin, C.; Brettmann, J.; Kyrychenko, A.; Palchevskyy, S.S.; Pucci, B.; Ladokhin, A.S. Interactions of fluorinated surfactants with diphtheria toxin T-domain: Testing new media for research of membrane proteins. Biophys. J. 2008, 94, 4348357. 44. Posokhov, Y.O.; Ladokhin, A.S. Lifetime fluorescence technique for figuring out membrane topology of proteins. Anal. Biochem. 2006, 348, 873. 45. Ladokhin, A.S.; Jayasinghe, S.; White, S.H. The way to measure and analyze tryptophan fluorescence in membranes adequately, and why bother Anal. Biochem. 2000, 285, 23545.Zidebactam 46. Chenal, A.; Prongidi-Fix, L.; Perier, A.; Aisenbrey, C.; Vernier, G.; Lambotte, S.; Haertlein, M.; Dauvergne, M.T.; Fragneto, G.; Bechinger, B.; et al. Deciphering membrane insertion of your diphtheria toxin T domain by specular neutron reflectometry and solid-state nmr spectroscopy. J. Mol. Biol. 2009, 391, 87283. 47. Wimalasena, D.S.; Cramer, J.C.; Janowiak, B.E.; Juris, S.J.; Melnyk, R.A.; Anderson, D.E.; Kirk, K.L.; Collier, R.J.; Bann, J.G. Effect of 2-fluorohistidine labeling in the anthrax protective antigen on stability, pore formation, and translocation. Biochemistry 2007, 46, 149284936. 48. Buckley, J.T.; Wilmsen, H.U.; Lesieur, C.; Schulze, A.; Pattus, F.; Parker, M.W.; van der Goot, F.G. Protonation of histidine-132 promotes oligomerization of your channel-forming toxin aerolysin. Biochemistry 1995, 34, 164506455. 49. Wimley, W.C.; White, S.H. Experimentally determined hydrophobicity scale for proteins at membrane interfaces. Nat. Struct. Biol. 1996, 3, 84248.Toxins 2013,50. Ren, J.; Kachel, K.; Kim, H.; Malenbaum, S.E.; Collier, R.J.; London, E. Interaction of diphtheria toxin t domain with molten globule-like proteins and its implications for translocation. Science 1999, 284, 95557. 51. Kakimoto, S.; Hamada, T.; Komatsu, Y.; Takagi, M.; Tanabe, T.; Azuma, H.Bafilomycin A1 ; Shinkai, S.PMID:32926338 ; Nagasaki, T. The conjugation of diphtheria toxin T domain to poly(ethylenimine) based vectors for enhanced endosomal escape in the course of gene transfection. Biomaterials 2009, 30, 40208. 52. Zhang, Y.; Schulte, W.; Pink, D.; Phipps, K.; Zijlstra, A.; Lewis, J.D.; Waisman, D.M. Sensitivity of cancer cells to truncated diphtheria toxin. PLoS One particular 2010, 5, e10498. 53. Wild, R.; Yokoyama, Y.; Dings, R.P.; Ramakrishnan, S. Vegf-dt385 toxin conjugate inhibits mammary adenocarcinoma development in a transgenic mouse model of spontaneous tumorigenesis. Breast Cancer Res. Treat. 2004, 85, 16171. 54. Urieto, J.O.; Liu, T.; Black, J.H.; Cohen, K.A.; Hall, P.D.; Willingham, M.C.; Pennell, L.K.; Hogge, D.E.; Kreitman, R.J.; Frankel, A.E. Expression and purification of the recombinant diphtheria fusion toxin dt388il3 for phase I clinical trials. Protein Expr. Purif. 2004, 33, 12333. 55. Turturro, F. Denileukin diftitox: A biotherapeutic paradigm shift in the remedy of lymphoid-derived issues. Expert Rev. Anticancer Ther. 2007, 7, 117. 56. Ramakrishnan, S.; Olson, T.A.; Bautch, V.L.; Mohanraj, D. Vascular endothelial development factor-toxin conjugate especially inhibits kdr/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res. 1996, 56, 1324330. 57. Ramage, J.G.; Vallera, D.A.; Black, J.H.; Aplan, P.D.; Kees, U.R.; Frankel, A.E. The diphtheria toxin/urokinase fusion protein (dtat) is selectively toxic to cd87 expressing leukemic cells.