Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This short article is distributed below the terms with the Inventive Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and Fingolimod (hydrochloride) site distribution of the work without additional permission offered the original perform is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).2 water content, volume, or frequency of stools.11 A reduce in consistency (ie, soft or liquid) and an increase in the frequency of bowel movements to 3 stools each day have normally been utilized as a definition for epidemiological investigations. Determined by a community-based study point of view, diarrhea is defined as a minimum of three or far more loose stools within a 24-hour period.12 A diarrheal episode is thought of as the passage of three or extra loose or liquid stools in 24 hours prior to presentation for care, which can be regarded as the most practicable in kids and adults.13 Nonetheless, prolonged and persistent diarrhea can final in between 7 and 13 days and at the least 14 days, respectively.14,15 The illness is extremely sensitive to climate, displaying seasonal variations in numerous websites.16 The climate sensitivity of diarrheal illness is consistent with observations with the direct effects of climate variables on the causative agents. Temperature and relative humidity have a direct influence around the price of replication of bacterial and protozoan pathogens and on the survival of enteroviruses within the atmosphere.17 Overall health care journal.pone.0169185 searching for is recognized to be a result of a complex behavioral method that is certainly influenced by several factors, such as socioeconomic and demographic and qualities, perceived need, accessibility, and service availability.Diseases constituted 9 of all deaths among children <5 years old in 2015.4 Although the burden of diarrheal diseases is much lower in developed countries, it is an important public health problem in low- and middle-income countries because the disease is particularly dangerous for young children, who are more susceptible to dehydration and nutritional losses in those settings.5 In Bangladesh, the burden of diarrheal diseases is significant among children <5 years old.6 Global estimates of the mortality resulting from diarrhea have shown a steady decline since the 1980s. However, despite all advances in health technology, improved management, and increased use of oral rehydrationtherapy, diarrheal diseases are also still a leading cause of public health concern.7 Moreover, morbidity caused by diarrhea has not declined as rapidly as mortality, and global estimates remain at between 2 and 3 episodes of diarrhea annually for children <5 years old.8 There are several studies assessing the prevalence of childhood diarrhea in children <5 years of age. However, in Bangladesh, information on the age-specific prevalence rate of childhood diarrhea is still limited, although such studies are vital for informing policies and allowing international comparisons.9,10 Clinically speaking, diarrhea is an alteration in a normal bowel movement characterized by an increase in theInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh 2 University of Strathclyde, Glasgow, UK Corresponding Author: Abdur Razzaque Sarker, Health Economics and Financing Research, International Centre for Diarrhoeal Disease Research, 68, Shaheed Tajuddin Sarani, Dhaka 1212, Bangladesh. Email: [email protected] Commons Non Commercial CC-BY-NC: a0023781 This article is distributed beneath the terms on the Inventive Commons Attribution-NonCommercial three.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits noncommercial use, reproduction and distribution with the work without having additional permission offered the original operate is attributed as specified around the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).2 water content, volume, or frequency of stools.11 A lower in consistency (ie, soft or liquid) and a rise within the frequency of bowel movements to three stools per day have frequently been used as a definition for epidemiological investigations. Depending on a community-based study viewpoint, diarrhea is defined as at the very least three or far more loose stools within a 24-hour period.12 A diarrheal episode is deemed because the passage of three or a lot more loose or liquid stools in 24 hours prior to presentation for care, which can be regarded essentially the most practicable in kids and adults.13 Having said that, prolonged and persistent diarrhea can last between 7 and 13 days and at least 14 days, respectively.14,15 The illness is extremely sensitive to climate, displaying seasonal variations in quite a few web sites.16 The climate sensitivity of diarrheal illness is constant with observations on the direct effects of climate variables around the causative agents. Temperature and relative humidity have a direct influence on the price of replication of bacterial and protozoan pathogens and on the survival of enteroviruses in the atmosphere.17 Health care journal.pone.0169185 in search of is recognized to be a outcome of a complicated behavioral Fingolimod (hydrochloride) approach that is certainly influenced by numerous components, which includes socioeconomic and demographic and characteristics, perceived have to have, accessibility, and service availability.