Ld-Samsoe B, Bennett R, et al. 1H NMR Spectroscopy-based interventional metabolic phenotyping: A cohort study of rheumatoid arthritis individuals. J Proteome Res 9: 45454553. 17. Madsen RK, Lundstedt T, Gabrielsson J, Sennbro CJ, Alenius GM, et al. Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Arthritis Res Ther 13. 18. Borenstein DG, Gibbs CA, Jacobs RP Gas-liquid chromatographic evaluation of synovial fluid. Arthritis Rheum 25: 947953. 19. Lee DY, Fiehn O Good quality metabolomic data for Chlamydomonas reinhardtii. Plant Strategies four: 7. 20. Fiehn O, Wohlgemuth G, Scholz M, Type T, Lee DY, et al. Excellent control for plant metabolomics: reporting MSI-compliant studies. Plant J 53: 691704. 21. Hutschenreuther A, Kiontke A, Birkenmeier G, Birkemeyer C Comparison of extraction situations and normalization approaches for cellular metabolomics of adherent developing cells with GC-MS. Anal Techniques four: 1953 1963. 22. Lee DY, Park JJ, Barupal DK, Fiehn O Technique Response of Metabolic Networks in Chlamydomonas reinhardtii to Total Out there Ammonium. Mol Cell Proteomics 11: 973988. 23. Denkert C, Budczies J, Sort T, Weichert W, Triptorelin web Tablack P, et al. Mass spectrometry-based metabolic profiling reveals distinct metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res 66: 1079510804. 24. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, et al. TM4 microarray Eledoisin chemical information computer software suite. Approaches Enzymol 411: 134193. 25. Umetrics AB User’s Guide to SIMCA-P, SIMCA-P+ version 11.0. Umea, Sweden: Umetrics AB. 26. Lalkhen AG, McCluskey A Clinical tests: sensitivity and specificity. Contin Educ Anaesth Crit Care Discomfort eight: 221223. 27. Swets JA Measuring the accuracy of diagnostic systems. Science 240: 12851293. 28. Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform 38: 404415. 29. Greiner M, Pfeiffer D, Smith RD Principles and practical application in the 25033180 receiver-operating characteristic evaluation for diagnostic tests. Prev Vet Med 45: 2341. 30. Mamas M, Dunn WB, Neyses L, Goodacre R The role of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch Toxicol 85: 5 17. 31. Madsen R, Lundstedt T, Trygg J Chemometrics in metabolomics-A assessment in human illness diagnosis. Anal Chim Acta 659: 2333. 32. Vinayavekhin N, Homan EA, Saghatelian A Exploring Disease by way of Metabolomics. ACS Chem Biol 5: 91103. 33. Zhai G, Wang-Sattler R, Hart DJ, Arden NK, Hakim AJ, et al. Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis 69: 12271231. 34. Hugle T, Kovacs H, Heijnen I, Daikeler T, Baisch U, et al. Synovial fluid metabolomics in different types of arthritis assessed by nuclear magnetic resonance spectroscopy. Clin Exp Rheumatol 30: 240245. 35. Tarcsa E, Marekov LN, Mei G, Melino G, Lee SC, et al. Protein unfolding by peptidylarginine deiminase Substrate specificity and structural 8 Metabolomics of Rheumatoid Arthritis Making use of Synovial Fluid relationships of your all-natural substrates trichohyalin and filaggrin. J Biol Chem 271: 3070930716. 36. Bas S, Perneger Tv, Seitz M, Tiercy JM, Roux-Lombard P, et al. Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid components. Rheumatology 41: 809814. 37. Jetten MSM, Pitoc GA, Follettie MT, Sinskey AJ Regulation of phospho-.Ld-Samsoe B, Bennett R, et al. 1H NMR Spectroscopy-based interventional metabolic phenotyping: A cohort study of rheumatoid arthritis patients. J Proteome Res 9: 45454553. 17. Madsen RK, Lundstedt T, Gabrielsson J, Sennbro CJ, Alenius GM, et al. Diagnostic properties of metabolic perturbations in rheumatoid arthritis. Arthritis Res Ther 13. 18. Borenstein DG, Gibbs CA, Jacobs RP Gas-liquid chromatographic analysis of synovial fluid. Arthritis Rheum 25: 947953. 19. Lee DY, Fiehn O Premium quality metabolomic information for Chlamydomonas reinhardtii. Plant Approaches four: 7. 20. Fiehn O, Wohlgemuth G, Scholz M, Sort T, Lee DY, et al. Top quality manage for plant metabolomics: reporting MSI-compliant research. Plant J 53: 691704. 21. Hutschenreuther A, Kiontke A, Birkenmeier G, Birkemeyer C Comparison of extraction situations and normalization approaches for cellular metabolomics of adherent expanding cells with GC-MS. Anal Strategies four: 1953 1963. 22. Lee DY, Park JJ, Barupal DK, Fiehn O Program Response of Metabolic Networks in Chlamydomonas reinhardtii to Total Offered Ammonium. Mol Cell Proteomics 11: 973988. 23. Denkert C, Budczies J, Type T, Weichert W, Tablack P, et al. Mass spectrometry-based metabolic profiling reveals distinctive metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res 66: 1079510804. 24. Saeed AI, Bhagabati NK, Braisted JC, Liang W, Sharov V, et al. TM4 microarray computer software suite. Methods Enzymol 411: 134193. 25. Umetrics AB User’s Guide to SIMCA-P, SIMCA-P+ version 11.0. Umea, Sweden: Umetrics AB. 26. Lalkhen AG, McCluskey A Clinical tests: sensitivity and specificity. Contin Educ Anaesth Crit Care Pain eight: 221223. 27. Swets JA Measuring the accuracy of diagnostic systems. Science 240: 12851293. 28. Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L The usage of receiver operating characteristic curves in biomedical informatics. J Biomed Inform 38: 404415. 29. Greiner M, Pfeiffer D, Smith RD Principles and sensible application with the 25033180 receiver-operating characteristic evaluation for diagnostic tests. Prev Vet Med 45: 2341. 30. Mamas M, Dunn WB, Neyses L, Goodacre R The part of metabolites and metabolomics in clinically applicable biomarkers of disease. Arch Toxicol 85: five 17. 31. Madsen R, Lundstedt T, Trygg J Chemometrics in metabolomics-A overview in human disease diagnosis. Anal Chim Acta 659: 2333. 32. Vinayavekhin N, Homan EA, Saghatelian A Exploring Disease by way of Metabolomics. ACS Chem Biol 5: 91103. 33. Zhai G, Wang-Sattler R, Hart DJ, Arden NK, Hakim AJ, et al. Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis. Ann Rheum Dis 69: 12271231. 34. Hugle T, Kovacs H, Heijnen I, Daikeler T, Baisch U, et al. Synovial fluid metabolomics in distinct types of arthritis assessed by nuclear magnetic resonance spectroscopy. Clin Exp Rheumatol 30: 240245. 35. Tarcsa E, Marekov LN, Mei G, Melino G, Lee SC, et al. Protein unfolding by peptidylarginine deiminase Substrate specificity and structural 8 Metabolomics of Rheumatoid Arthritis Applying Synovial Fluid relationships in the organic substrates trichohyalin and filaggrin. J Biol Chem 271: 3070930716. 36. Bas S, Perneger Television, Seitz M, Tiercy JM, Roux-Lombard P, et al. Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid components. Rheumatology 41: 809814. 37. Jetten MSM, Pitoc GA, Follettie MT, Sinskey AJ Regulation of phospho-.