Puyal et al. confirmed that transient middle cerebral artery occlusion (MCAO) increased the quantities of cathepsin D, LAMP1-constructive neurons in neonatal rats. Moreover, double labeling confirmed that the sturdy punctuate autophagosomal labeling

(B) In sham-operated animals, cortical cells displayed good, granular, and perinuclear cathepsin-B staining. Immediately after I/R, cathepin-B granules turned progressively more substantial and irregular, and the granular pattern was eventually…